Cannabis customers have 55% much less probabilities of developing one particular of the most typical malignancies worldwide — hepatocellular carcinoma (HCC), according to a study published this yr in the health care journal Cureus.
HCC is regarded the fourth top induce of most cancers fatalities in the entire world, and centered on a analyze that analyzed details for hundreds of thousands of persons in the National Inpatient Sample (NIS) databases, cannabis customers have appreciably reduced prospects of building this ailment.
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Scientists from Georgetown College Hospital and the Cleveland Clinic, who led the examine, claimed that the association among HCC and marijuana has presently been observed in ice, but to their understanding, it hadn’t however been confirmed in humans.
The examine utilized information from the NIS database among 2002 and 2014 and provided a whole of 101.23 million individuals. Out of the whole, 996,290 have been sufferers who consume marijuana, although the manage group with no hashish utilization bundled 100.23 clients.
“We found that patients with hashish abuse were being more youthful (34 vs 48 a long time), had much more males (61.7% vs 41.4%) and extra African People (29.9% vs 14.2%) as opposed with the manage group (P<0.001 for all). Besides, patients with cannabis use had more hepatitis B, hepatitis C, liver cirrhosis, and smoking, but had less obesity and gallstones,” the study authors said.
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And while the study revealed that “patients with cannabis abuse were 55% less likely to have HCC compared with patients without cannabis abuse,” the researchers highlighted that this only confirms correlation and that they could not definitely confirm direct causation.
“We suggest prospective clinical studies to further understand the mechanism by which various active ingredients, particularly CBD in cannabis, may possibly regulate hepatocellular carcinoma development,” they wrote.
Pre-Clinical Study Showing Cannabinoid Therapies Stop Liver Cancer Growth
While this study does not confirm that marijuana can keep people’s livers safe from HCC, other recent studies are closely in line with the suggestion. In April, the biotech company, Can-Fite BioPharma completed pre-clinical studies demonstrating cannabinoid-based therapies stop liver cancer growth. The studies showed that CBD-rich T3/C15 cannabis fraction inhibited the growth of liver HEP-3b hepatocellular carcinoma cells via the A3AR by inhibiting Wnt- and NF-kappa B-related regulatory pathways. The company’s lead drug candidate Namodenoson is expected to enter the Phase 3 study in Q4 2021.
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Previous Studies On Marijuana And Cancer
Colon Cancer: In March, An Israeli biotech company that develops medical products based on cannabis and fungal extracts, Cannabotech reported cell model study results showing that its “Integrative-Colon” products killed over 90% of colon cancer cells. The Integrative-Colon products are based on a combination of several cannabinoids from the cannabis plant and various mushroom extracts.
Pancreatic Cancer: Experiments conducted on a cell model showed that a botanical drug based on an extract of the Cyathus striatus fungus and a cannabinoid extract from the cannabis plant eliminated 100% of pancreatic cancer cells relatively selectively and without damaging normal cells. The results were revealed in April 2022.
Breast Cancer: A study conducted by Hadassah Medical Center physicians and published in December revealed a sixfold improvement in killing breast cancer cells when using specific Cannabotech’s medical cannabis products in combination with standard oncology treatments and drug protocols such as chemotherapy, biological and hormonal, over the existing treatment.
This article originally appeared on Benzinga and has been reposted with permission.